DNA and RNA Technology
Powered by Monoclonal Antibodies
Our monoclonal antibodies are precisely designed to read distinct features of nucleic acids and power DNA and RNA sensing technologies. The unique properties of our antibodies facilitate broad applications from studies of DNA damage and repair in disease to quality control in the production of mRNA therapeutics.
Sensing Change in DNA and RNA
Nucleic acids are subject to chemical modifications during normal cellular function or as accumulated damage under stressful conditions. Oxidative damage is a particularly abundant and deleterious type of lesion that has been implicated in many pathological states. We discover and develop innovative molecular solutions to sense and install chemical modifications in multiple formats including mRNA, DNA, and free nucleosides.
Quality Control Solutions
Our antibody portfolio is tailored to meet the needs of scientists probing nucleic acid biology and addressing challenges associated with therapeutic nucleic acid development such as damage detection and pharmacokinetic studies. From neurodegeneration and cancer to manufacturing and tissue distribution, carefully tracking DNA and RNA modifications with spatial and temporal resolution is a critical element of quality control.
Broad Biological Significance
Oxidative and chemical damage to DNA and RNA occurs during cancer, neurodegenerative disease, exposure to ionizing radiation, and metabolic stress. The damage must be removed to avoid production of pathological, misfolded proteins and immunogenicity. Damage to an RNA therapeutic arising during manufacturing, storage, or after patient administration may impair safety and quality control, reducing the efficacy of the drug product.